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Black Sesame Extract sesamin





sesamin Black Sesame Extract Sesamum indicum L






sesamin Herb Source

Sesamum indicum L. Zanthoxylum acanthapodium var. villosum Huang. Piper longum


sesamin Molecular Formula and Molecular Weight






sesamin Melting Point

122 -123


sesamin Solubility

sesamin Freely soluble in chloroform-benzene-acetic acid and acetone.




sesamin Pharmacology

Antioxidant Bactericide Insecticide Non-competitive D5-desaturase inhibitor.

Sesamin is an all-natural component stored in sesame seeds. Its content is only about 0.5 percent. Through extracting sesamin from sesame, and experimenting in animals and humans, the Japanese scientific researchers have discovered that sesamin has effects of preventing hypertension and cardiovascular hypertrophy, protecting liver, resisting oxidation, reducing cholesterol, and anti-cancer .


Effect of sesamin, a sesame lignan, on the hepatic fatty acid metabolism was examined in the rat.

Increase of the dietary level of sesamin progressively increased the mitochondrial and peroxisomal

fatty acid oxidation rate. Mitochondrial activity almost doubled in rats fed a 0.5% sesamin diet. Peroxisomal

activity became more than 10 times higher in rats fed a 0.5% sesamin diet, compared to those

fed a sesamin-free diet. Dietary sesamin also markedly increased the hepatic activity and mRNA levels

of various fatty acid oxidation enzymes. In contrast, dietary sesamin decreased the hepatic activity

and mRNA abundance of lipogenic enzymes. This was associated with the down-regulation of sterol

regulatory element-binding protein-1, a transcriptional factor that regulates the lipogenic enzyme gene

expression. Dietary sesamin significantly decreased the triacylglycerol secretion accompanying the

increase in ketone body production by the perfused rat liver. It is apparent that sesamin affects the fatty

acid metabolism and lipoprotein production in the liver, and hence lowers the serum lipid levels. We

also developed several sesame lines with seeds containing sesamin and sesamolin at twice the concentration

of conventional cultivars. Compared to a conventional cultivar, these lignan-rich sesame seeds

increased the hepatic fatty acid oxidation rate and lowered the serum triacylglycerol level in the rat.

Therefore, it is considered that enrichment of the lignans potentiates the characteristics of sesame in

improving human health.


Sesamin, one of the lignans present most abundantly

in sesame seed and oil (Fig. 1), markedly influences the

lipid metabolism in experimental animals. Sesamin feeding

is associated with a reduction of serum lipid levels in

rodents7,8,22. This compound is also effective in preventing

an increase in the serum triacylglycerol level following

ethanol consumption in the rat1. The cholesterollowering

effect of sesamin has also been demonstrated in humans6. However, the mechanism(s) underlying the

lipid-lowering effect of sesamin remains to be clarified.

The changes in the rate of fatty acid synthesis and oxidation

in the liver may possibly modify serum lipid concentrations.

Alterations in fatty acid synthesis25 and

oxidation10,11 which affect the availability of fatty acids

for triacylglycerol synthesis, and in turn modify the very

low density lipoprotein production by the liver, may

affect the serum lipid levels. In this context, we examined

the physiological activity of sesamin in relation to

the hepatic fatty acid metabolism in the rat.






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Organic Herb Inc.




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